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Literature summary extracted from

  • Selberg, S.; Blokhina, D.; Aatonen, M.; Koivisto, P.; Siltanen, A.; Mervaala, E.; Kankuri, E.; Karelson, M.
    Discovery of small molecules that activate RNA methylation through cooperative binding to the METTL3-14-WTAP complex active site (2019), Cell Rep., 26, 3762-3771 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.348 methyl 6-methylpiperidine-3-carboxylate
-
 Homo sapiens
2.1.1.348 methyl piperazine-2-carboxylate potent activator Homo sapiens
2.1.1.348 methyl piperidine-3-carboxylate
-
 Homo sapiens
2.1.1.348 tert-butyl 6-methylpiperidine-3-carboxylate
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.348 S-adenosyl-L-homocysteine
-
 Homo sapiens
2.1.1.348 sinefungin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Homo sapiens Q86U44
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.348 HEK-293 cell
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.348 0.00236
-
 pH and temperature not specified in the publication Homo sapiens sinefungin
2.1.1.348 0.281
-
 pH and temperature not specified in the publication Homo sapiens S-adenosyl-L-homocysteine

General Information

EC Number General Information Comment Organism
2.1.1.348 drug target activators of METTL3-14-WTAP can be potential anticancer agents against glioblastoma Homo sapiens